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Chemical structure of AZD3839

GC14130

AZD3839

Also known as (3S)-3-[2-(difluoromethyl)-4-pyridinyl]-7-fluoro-3-(3-pyrimidin-5-ylphenyl)isoindol-1-amine

AZD3839 is a potent and selective orally active, brain-permeable BACE1 inhibitor (Ki=26 nM)· AZD3839 shows 14 and >1000-fold selectivity against BACE2 and cathepsin D, respectively· AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid Aβ levels in mouse, guinea pig, and non-human primate· AZD3839 can be used for the research of Alzheimer's disease

ChemicalCAS1227163-84-9MW431.41FormulaC24H16F3N5
CAS number
1227163-84-9
Molecular weight
431.41
Formula
C24H16F3N5
Solubility
DMF： 2 mg/ml,DMSO： 30 mg/ml,Ethanol： 30 mg/ml,Ethanol：PBS (pH 7·2) (1：1)： 0·5 mg/ml
InChIKey
MRXBCEQZNKUUIP-DEOSSOPVSA-N
Catalogue number
GC14130
Brand
GLPBIO
Computed properties PubChem CID 46202416 · XLogP 3.2 · TPSA 77.1 Ų · H-bond donors 1
XLogP
3.2
TPSA
77.1 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
32

SMILES C1=CC(=CC(=C1)[C@@]2(C3=C(C(=CC=C3)F)C(=N2)N)C4=CC(=NC=C4)C(F)F)C5=CN=CN=C5

Computed descriptors from PubChem (CID 46202416), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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