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Chemical structure of AZD3759

GC13143

AZD3759

Also known as [4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl] (2R)-2,4-dimethylpiperazine-1-carboxylate

AZD3759 (AZD3759) is a potent, orally active, central nervous system-penetrant, EGFR inhibitor· At Km ATP concentrations, the IC50s are 0·3, 0·2, and 0·2 nM for EGFRwt, EGFRL858R, and EGFRexon 19Del, respectively

ChemicalCAS1626387-80-1MW459.9FormulaC22H23ClFN5O3
CAS number
1626387-80-1
Molecular weight
459.9
Formula
C22H23ClFN5O3
Solubility
≥ 23mg/mL in DMSO
InChIKey
MXDSJQHFFDGFDK-CYBMUJFWSA-N
Catalogue number
GC13143
Brand
GLPBIO
Computed properties PubChem CID 78209992 · XLogP 4.1 · TPSA 79.8 Ų · H-bond donors 1
XLogP
4.1
TPSA
79.8 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
32

SMILES C[C@@H]1CN(CCN1C(=O)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC)C

Computed descriptors from PubChem (CID 78209992), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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