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Chemical structure of AZD3458

GC65149

AZD3458

Also known as N-[5-[2-[(1S)-1-cyclopropylethyl]-7-methylsulfonyl-1-oxo-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]acetamide

AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9·1, 5·1, ＜4·5, and 6·5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively

ChemicalCAS2132961-46-5MW433.54FormulaC20H23N3O4S2
CAS number
2132961-46-5
Molecular weight
433.54
Formula
C20H23N3O4S2
Solubility
DMSO ： 250 mg/mL (576·65 mM; Need ultrasonic)
InChIKey
PAQUFWFUOVDUIO-NSHDSACASA-N
Catalogue number
GC65149
Brand
GLPBIO
Computed properties PubChem CID 134611894 · XLogP 2 · TPSA 133 Ų · H-bond donors 1
XLogP
2
TPSA
133 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
29

SMILES CC1=C(SC(=N1)NC(=O)C)C2=CC3=C(C(=C2)S(=O)(=O)C)C(=O)N(C3)[C@@H](C)C4CC4

Computed descriptors from PubChem (CID 134611894), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.