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Chemical structure of MK-4827 hydrochloride

GC12756

MK-4827 hydrochloride

Also known as 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide;hydrochloride

MK-4827 hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3·8 and 2·1 nM, respectively· MK-4827 hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity

ChemicalCAS1038915-64-8MW356.85FormulaC19H21ClN4O
CAS number
1038915-64-8
Molecular weight
356.85
Formula
C19H21ClN4O
Solubility
Soluble in DMSO
InChIKey
YXYDNYFWAFBCAN-PFEQFJNWSA-N
Catalogue number
GC12756
Brand
GLPBIO
Computed properties PubChem CID 44550597 · TPSA 72.9 Ų · H-bond donors 3 · H-bond acceptors 3
TPSA
72.9 Ų
H-bond donors
3
H-bond acceptors
3
Rotatable bonds
3
Heavy atoms
25

SMILES C1C[C@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N.Cl

Computed descriptors from PubChem (CID 44550597), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.