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Chemical structure of MK-4827 tosylate

GC11537

MK-4827 tosylate

Also known as 4-methylbenzenesulfonic acid;2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide

MK-4827 tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3·8 and 2·1 nM, respectively· MK-4827 tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity

ChemicalCAS1038915-73-9MW492.59FormulaC26H28N4O4S
CAS number
1038915-73-9
Molecular weight
492.59
Formula
C26H28N4O4S
Solubility
DMF： 30 mg/ml,DMSO： 30 mg/ml,DMSO：PBS (pH 7·2) (1：6)： 0·14 mg/ml,Ethanol： 1 mg/ml
InChIKey
LCPFHXWLJMNKNC-PFEQFJNWSA-N
Catalogue number
GC11537
Brand
GLPBIO
Computed properties PubChem CID 78357761 · TPSA 136 Ų · H-bond donors 3 · H-bond acceptors 6
TPSA
136 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
35

SMILES CC1=CC=C(C=C1)S(=O)(=O)O.C1C[C@H](CNC1)C2=CC=C(C=C2)N3C=C4C=CC=C(C4=N3)C(=O)N

Computed descriptors from PubChem (CID 78357761), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.