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Chemical structure of GDC-0994

GC12006

GDC-0994

Also known as 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one

GDC-0994 (GDC-0994) is an orally active ERK kinase inhibitor with an IC50 of 6·1 nM and 3·1 nM for ERK1 and ERK2, respectively

ChemicalCAS1453848-26-4MW440.86FormulaC21H18ClFN6O2
CAS number
1453848-26-4
Molecular weight
440.86
Formula
C21H18ClFN6O2
Solubility
≥ 44·1mg/mL in DMSO
InChIKey
RZUOCXOYPYGSKL-GOSISDBHSA-N
Catalogue number
GC12006
Brand
GLPBIO
Computed properties PubChem CID 71727581 · XLogP 2 · TPSA 96.2 Ų · H-bond donors 2
XLogP
2
TPSA
96.2 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
31

SMILES CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)[C@H](CO)C4=CC(=C(C=C4)Cl)F

Computed descriptors from PubChem (CID 71727581), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.