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Chemical structure of Apitolisib

GC11177

Apitolisib

Also listed as GDC-0980 (RG7422)

GDC-0980 (RG7422) (GDC-0980; GNE 390; RG 7422) is a selective, potent, orally bioavailable Class I PI3 kinase and mTOR kinase (TORC1/2) inhibitor with IC50s of 5 nM/27 nM/7 nM/14 nM for PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ, and with aKiof 17 nM for mTOR

ChemicalCAS1032754-93-0MW498.61FormulaC23H30N8O3S
CAS number
1032754-93-0
Molecular weight
498.61
Formula
C23H30N8O3S
Solubility
≥ 21·35mg/mL in DMSO
InChIKey
YOVVNQKCSKSHKT-HNNXBMFYSA-N
Catalogue number
GC11177
Brand
GLPBIO
Computed properties PubChem CID 25254071 · XLogP 0.2 · TPSA 162 Ų · H-bond donors 2
XLogP
0.2
TPSA
162 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
5
Heavy atoms
35

SMILES CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[C@H](C)O

Computed descriptors from PubChem (CID 25254071), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.