GB40369
SIS3 free base
Also listed as SIS3 - Smad3 inhibitor SIS3
SIS3 is a potent and selective inhibitor of Smad3 and TGF-β signaling· Inhibition by SIS3 leads to abrogation of the TGF-β1-induced production of extracellular matrix proteins in normal fibroblasts and scleroderma fibroblasts· Moreover, Smad3 inhibition attenuates resistance to anti-HER2 drugs in HER2-positive breast cancer cells
ChemicalCAS521985-36-4MW453.53FormulaC28H27N3O3
- CAS number
- 521985-36-4
- Molecular weight
- 453.53
- Formula
- C28H27N3O3
- Solubility
- DMSO ： 100 mg/mL (220·49 mM; Need ultrasonic)
- InChIKey
- IJYPHMXWKKKHGT-VAWYXSNFSA-N
- Catalogue number
- GB40369
- Brand
- GLPBIO
Computed properties PubChem CID 10138988 · XLogP 4.3 · TPSA 56.6 Ų · H-bond donors 0
- XLogP
- 4.3
- TPSA
- 56.6 Ų
- H-bond donors
- 0
- H-bond acceptors
- 4
- Rotatable bonds
- 5
- Heavy atoms
- 34
SMILES CN1C(=C(C2=C1N=CC=C2)/C=C/C(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5
Computed descriptors from PubChem (CID 10138988), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il