GC17191
SIS3 HCl
Also known as (E)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride
SIS3 HCl is a Smad3 inhibitor that inhibits the phosphorylation of Smad3 with an IC50 of 3 μM
ChemicalCAS521984-48-5MW489.99FormulaC28H28ClN3O3
- CAS number
- 521984-48-5
- Molecular weight
- 489.99
- Formula
- C28H28ClN3O3
- Solubility
- ≥ 49 mg/mL in DMSO, ≥ 11 mg/mL in EtOH with ultrasonic and warming
- InChIKey
- CDKIEBFIMCSCBB-CALJPSDSSA-N
- Catalogue number
- GC17191
- Brand
- GLPBIO
Computed properties PubChem CID 16079005 · TPSA 56.6 Ų · H-bond donors 1 · H-bond acceptors 4
- TPSA
- 56.6 Ų
- H-bond donors
- 1
- H-bond acceptors
- 4
- Rotatable bonds
- 5
- Heavy atoms
- 35
SMILES CN1C(=C(C2=C1N=CC=C2)/C=C/C(=O)N3CCC4=CC(=C(C=C4C3)OC)OC)C5=CC=CC=C5.Cl
Computed descriptors from PubChem (CID 16079005), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il