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Chemical structure of PROTAC RAF Degrader 1

GC91586

PROTAC RAF Degrader 1

Also known as (2S,4R)-1-[(2S)-2-[[2-[4-[4-[3-[2,6-difluoro-3-(propylsulfonylamino)benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]piperazin-1-yl]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

PROTAC RAF degrader 1 is a proteolysis-targeting chimera (PROTAC) that contains the inhibitor of mutant V600E and wild-type B-RAF vemurafenib (PLX4032; ) conjugated to VHL ligand 1

ChemicalCAS2413035-41-1MW1010.2FormulaC51H57F2N9O7S2
CAS number
2413035-41-1
Molecular weight
1010.2
Formula
C51H57F2N9O7S2
Solubility
Acetonitrile： Slightly soluble： 0·1–1 mg/ml,DMSO： Sparingly soluble： 1–10 mg/ml
InChIKey
MBCAVOCJJAQHHT-FGUOTCRGSA-N
Catalogue number
GC91586
Brand
GLPBIO
Computed properties PubChem CID 146547699 · XLogP 6.4 · TPSA 247 Ų · H-bond donors 5
XLogP
6.4
TPSA
247 Ų
H-bond donors
5
H-bond acceptors
15
Rotatable bonds
17
Heavy atoms
71

SMILES CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)N5CCN(CC5)CC(=O)N[C@H](C(=O)N6C[C@@H](C[C@H]6C(=O)NCC7=CC=C(C=C7)C8=C(N=CS8)C)O)C(C)(C)C)F

Computed descriptors from PubChem (CID 146547699), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.