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Chemical structure of PROTAC B-Raf degrader 1

GC65479

PROTAC B-Raf degrader 1

Also known as N-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]-2-oxoethyl]-2-[2-methoxy-5-[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonylmethyl]anilino]acetamide

PROTAC B-Raf degrader 1 (compound 2) is a proteolysis targeting chimera (PROTAC) for the degradation of B-Raf based on Cereblon ligand with anti-cancer activity

ChemicalCAS2364367-27-9MW763.77FormulaC36H37N5O12S
CAS number
2364367-27-9
Molecular weight
763.77
Formula
C36H37N5O12S
Solubility
DMSO ： 25 mg/mL (32·73 mM; Need ultrasonic)
InChIKey
AMOFJSISJOOLNX-OUKQBFOZSA-N
Catalogue number
GC65479
Brand
GLPBIO
Computed properties PubChem CID 138319681 · XLogP 2 · TPSA 233 Ų · H-bond donors 4
XLogP
2
TPSA
233 Ų
H-bond donors
4
H-bond acceptors
13
Rotatable bonds
15
Heavy atoms
54

SMILES COC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)NCC(=O)NC3=CC=CC4=C3C(=O)N(C4=O)C5CCC(=O)NC5=O

Computed descriptors from PubChem (CID 138319681), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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