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Chemical structure of BI-4732

GC75735

BI-4732

Also known as (1R,4R)-5-[2-[(8aR)-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[1,2-a]pyrazin-2-yl]-6-[6-(4-methoxy-3-pyridinyl)-4-methylpyrazolo[4,3-c]pyridin-1-yl]-1-methylimidazo[4,5-c]pyridin-4-yl]-2-oxa-5-azabicyclo[2.2.1]heptane

BI-4732 a potent inhibitor EGFR-activating (E19del and L858R) and T790M mutations, with high blood-brian barrier penetration, targeting a broad range of EGFR mutations, including C797S

ChemicalCAS2769715-68-4MW592.69FormulaC32H36N10O2
CAS number
2769715-68-4
Molecular weight
592.69
Formula
C32H36N10O2
Solubility
DMSO： 2 mg/mL (3·37 mM; ultrasonic and warming and heat to 60°C)
InChIKey
WWLFWVFVYAPDGW-YPAWHYETSA-N
Catalogue number
GC75735
Brand
GLPBIO
Computed properties PubChem CID 164514234 · XLogP 3.1 · TPSA 102 Ų · H-bond donors 0
XLogP
3.1
TPSA
102 Ų
H-bond donors
0
H-bond acceptors
10
Rotatable bonds
5
Heavy atoms
44

SMILES CC1=C2C=NN(C2=CC(=N1)C3=C(C=CN=C3)OC)C4=NC(=C5C(=C4)N(C(=N5)N6CCN7CCC[C@@H]7C6)C)N8C[C@H]9C[C@@H]8CO9

Computed descriptors from PubChem (CID 164514234), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.