Loading...
Chemical structure of PROTAC KRAS G12D degrader 1

GC75732

PROTAC KRAS G12D degrader 1

Also known as (2S,4R)-1-[(2S)-2-[[2-[4-[(2S)-2-[[4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-7-(8-ethyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoropyrido[4,3-d]pyrimidin-2-yl]oxymethyl]pyrrolidin-1-yl]butoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

PROTAC KRAS G12D degrader 1 is a potent, rapid, and selective degrader of protac KRASG12D with DC50 of 38·06 nM

ChemicalCAS3033583-54-6MW1103.33FormulaC59H72F2N10O7S
CAS number
3033583-54-6
Molecular weight
1103.33
Formula
C59H72F2N10O7S
Solubility
DMSO： 10 mg/mL (9·06 mM; ultrasonic and warming and heat to 60°C)
InChIKey
KHIURKSPHCFKCV-FQLPBZNCSA-N
Catalogue number
GC75732
Brand
GLPBIO
Computed properties PubChem CID 170453287 · XLogP 8.4 · TPSA 236 Ų · H-bond donors 5
XLogP
8.4
TPSA
236 Ų
H-bond donors
5
H-bond acceptors
17
Rotatable bonds
20
Heavy atoms
79

SMILES CCC1=C(C=CC2=CC(=CC(=C21)C3=NC=C4C(=C3F)N=C(N=C4N5CC6CCC(C5)N6)OC[C@@H]7CCCN7CCCCOCC(=O)N[C@H](C(=O)N8C[C@@H](C[C@H]8C(=O)N[C@@H](C)C9=CC=C(C=C9)C1=C(N=CS1)C)O)C(C)(C)C)O)F

Computed descriptors from PubChem (CID 170453287), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.