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Chemical structure of PROTAC KRAS G12C degrader-2

GC73493

PROTAC KRAS G12C degrader-2

Also known as 5-[4-[[4-[(2R)-2-[6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)-4-(4-prop-2-enoylpiperazin-1-yl)quinazolin-2-yl]oxypropyl]piperazin-1-yl]methyl]piperidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

PROTAC KRAS G12C degrader-2 (compound 432) is a modulator of K-Ras protein drolysis

ChemicalCAS2378257-72-6MW958.47FormulaC51H53ClFN9O7
CAS number
2378257-72-6
Molecular weight
958.47
Formula
C51H53ClFN9O7
Solubility
DMSO ： 50 mg/mL (52·17 mM; Need ultrasonic)
InChIKey
KZQITCSEFGTWRQ-OWAVIYFHSA-N
Catalogue number
GC73493
Brand
GLPBIO
Computed properties PubChem CID 162472193 · XLogP 6.5 · TPSA 172 Ų · H-bond donors 2
XLogP
6.5
TPSA
172 Ų
H-bond donors
2
H-bond acceptors
14
Rotatable bonds
11
Heavy atoms
69

SMILES C[C@H](CN1CCN(CC1)CC2CCN(CC2)C3=CC4=C(C=C3)C(=O)N(C4=O)C5CCC(=O)NC5=O)OC6=NC7=C(C(=C(C=C7C(=N6)N8CCN(CC8)C(=O)C=C)Cl)C9=CC(=CC1=CC=CC=C19)O)F

Computed descriptors from PubChem (CID 162472193), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.