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Chemical structure of TNG348

GC75715

TNG348

Also known as 2-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-9-[[4-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]-7-(2,2,2-trifluoroethyl)purin-8-imine

TNG348 is an orally active ubiquitin-specific protease USP1 inhibitor that can be used in research on cancers with BRCA1/2 mutations or HRD+ (Homologous Recombination Deficiency positive) status

ChemicalCAS2839740-79-1MW603.52FormulaC27H23F6N9O
CAS number
2839740-79-1
Molecular weight
603.52
Formula
C27H23F6N9O
Solubility
DMSO： 100 mg/mL (165·69 mM; Need ultrasonic)
InChIKey
NKGSHRLGUQURMS-UHFFFAOYSA-N
Catalogue number
GC75715
Brand
GLPBIO
Computed properties PubChem CID 165135384 · XLogP 3.7 · TPSA 109 Ų · H-bond donors 1
XLogP
3.7
TPSA
109 Ų
H-bond donors
1
H-bond acceptors
13
Rotatable bonds
7
Heavy atoms
43

SMILES CN1C=C(N=C1C2=CC=C(C=C2)CN3C4=NC(=NC=C4N(C3=N)CC(F)(F)F)C5=C(N=CN=C5OC)C6CC6)C(F)(F)F

Computed descriptors from PubChem (CID 165135384), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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