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Chemical structure of FD274

GC75561

FD274

Also known as N-[2-chloro-5-(3-pyridin-4-yl-2H-pyrazolo[3,4-b]pyridin-5-yl)-3-pyridinyl]-4-fluorobenzenesulfonamide

FD274 is a highly potent PI3K/mTOR dual inhibitor with IC50s of 0·65 nM, 1·57 nM, 0·65 nM, 0·42 nM, and 2·03 nM against PI3Kα/β/γ/δ and mTOR, respectively

ChemicalCAS2641899-38-7MW480.9FormulaC22H14ClFN6O2S
CAS number
2641899-38-7
Molecular weight
480.9
Formula
C22H14ClFN6O2S
Solubility
DMSO： 125 mg/mL (259·93 mM; Need ultrasonic)
InChIKey
RVHGXIUOUJYWPJ-UHFFFAOYSA-N
Catalogue number
GC75561
Brand
GLPBIO
Computed properties PubChem CID 168476157 · XLogP 3.6 · TPSA 122 Ų · H-bond donors 2
XLogP
3.6
TPSA
122 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
33

SMILES C1=CC(=CC=C1F)S(=O)(=O)NC2=C(N=CC(=C2)C3=CC4=C(NN=C4N=C3)C5=CC=NC=C5)Cl

Computed descriptors from PubChem (CID 168476157), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.