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Chemical structure of FD223

GC62973

FD223

Also known as N-[2-chloro-5-(1H-pyrazolo[3,4-b]pyridin-5-yl)-3-pyridinyl]benzenesulfonamide

FD223 is a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor· FD223 displays high potency (IC50=1 nM) and good selectivity over other isoforms (IC50s of 51 nM, 29 nM and 37 nM, respectively for α, β and γ)· FD223 exhibits efficient inhibition of the proliferation of acute myeloid leukemia (AML) cell lines by suppressing p-AKT Ser473 thus causing G1 phase arrest during the cell cycle· FD223 has potential for the research of leukemia such as AML

ChemicalCAS2050524-24-6MW385.83FormulaC17H12ClN5O2S
CAS number
2050524-24-6
Molecular weight
385.83
Formula
C17H12ClN5O2S
Solubility
DMSO ： 100 mg/mL (259·18 mM; Need ultrasonic)
InChIKey
VFNUYVJFDQOTNJ-UHFFFAOYSA-N
Catalogue number
GC62973
Brand
GLPBIO
Computed properties PubChem CID 141461656 · XLogP 2.9 · TPSA 109 Ų · H-bond donors 2
XLogP
2.9
TPSA
109 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
26

SMILES C1=CC=C(C=C1)S(=O)(=O)NC2=C(N=CC(=C2)C3=CN=C4C(=C3)C=NN4)Cl

Computed descriptors from PubChem (CID 141461656), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.