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Chemical structure of BGB-8035

GC75398

BGB-8035

Also known as (7S)-2-(3,5-dimethoxy-4-methylphenyl)-7-(1-prop-2-enoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

BGB-8035 is an orally active, highly selective bruton's tyrosine kinase (BTK) inhibitor with IC50s of 1·1 nM, 99 nM, 621 nM for BTK, TEC, EGFR, respectively

ChemicalCAS2283349-24-4MW453.53FormulaC24H31N5O4
CAS number
2283349-24-4
Molecular weight
453.53
Formula
C24H31N5O4
InChIKey
ZFDGMDVYMNWICG-KRWDZBQOSA-N
Catalogue number
GC75398
Brand
GLPBIO
Computed properties PubChem CID 146623164 · XLogP 2.3 · TPSA 112 Ų · H-bond donors 2
XLogP
2.3
TPSA
112 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
33

SMILES CC1=C(C=C(C=C1OC)C2=NN3[C@@H](CCNC3=C2C(=O)N)C4CCN(CC4)C(=O)C=C)OC

Computed descriptors from PubChem (CID 146623164), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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