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Chemical structure of BGB-283

GC19066

BGB-283

Also known as 5-[[(1S,1aR,6bS)-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl]oxy]-3,4-dihydro-1H-1,8-naphthyridin-2-one

BGB-283 is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively

ChemicalCAS1446090-77-2MW478.42FormulaC25H17F3N4O3
CAS number
1446090-77-2
Molecular weight
478.42
Formula
C25H17F3N4O3
Solubility
DMSO ： ≥ 125 mg/mL (261·28 mM)
InChIKey
NGFFVZQXSRKHBM-YPAWHYETSA-N
Catalogue number
GC19066
Brand
GLPBIO
Computed properties PubChem CID 89670173 · XLogP 3.7 · TPSA 89.1 Ų · H-bond donors 2
XLogP
3.7
TPSA
89.1 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
3
Heavy atoms
35

SMILES C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)O[C@@H]5[C@H]4[C@H]5C6=NC7=C(N6)C=C(C=C7)C(F)(F)F

Computed descriptors from PubChem (CID 89670173), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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