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Chemical structure of PRMT5-IN-35

GC73908

PRMT5-IN-35

Also known as (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-(4-chlorophenyl)-hydroxymethyl]oxolane-3,4-diol

PRMT5-IN-35 (Compound 87) is a potent, selective and orally active PRMT5 inhibitor with an IC50 value of 1 nM

ChemicalCAS1989620-03-2MW376.79FormulaC17H17ClN4O4
CAS number
1989620-03-2
Molecular weight
376.79
Formula
C17H17ClN4O4
Solubility
DMSO ： 125 mg/mL (331·75 mM; Need ultrasonic)
InChIKey
ITEKIFMGFZAFPM-QFRSUPTLSA-N
Catalogue number
GC73908
Brand
GLPBIO
Computed properties PubChem CID 122497020 · XLogP 0.8 · TPSA 127 Ų · H-bond donors 4
XLogP
0.8
TPSA
127 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
3
Heavy atoms
26

SMILES C1=CC(=CC=C1[C@H]([C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C(N=CN=C43)N)O)O)O)Cl

Computed descriptors from PubChem (CID 122497020), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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