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Chemical structure of PRMT5-IN-25

GC73191

PRMT5-IN-25

Also known as 2-amino-3-methyl-N-[(1R)-1-pyrimidin-2-ylethyl]-N-[[5-(trifluoromethyl)-2-pyridinyl]methyl]quinoline-6-carboxamide

PRMT5-IN-25 (compound 503) is a potent PRMT5 inhibitor with an Ki value of 0·06 nM

ChemicalCAS2691869-82-4MW466.46FormulaC24H21F3N6O
CAS number
2691869-82-4
Molecular weight
466.46
Formula
C24H21F3N6O
Solubility
DMSO ： 62·5 mg/mL (133·99 mM; ultrasonic and warming and heat to 60°C)
InChIKey
QRZCNKOBDDQUAP-OAHLLOKOSA-N
Catalogue number
GC73191
Brand
GLPBIO
Computed properties PubChem CID 156830143 · XLogP 3.2 · TPSA 97.9 Ų · H-bond donors 1
XLogP
3.2
TPSA
97.9 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
34

SMILES CC1=CC2=C(C=CC(=C2)C(=O)N(CC3=NC=C(C=C3)C(F)(F)F)[C@H](C)C4=NC=CC=N4)N=C1N

Computed descriptors from PubChem (CID 156830143), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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