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Chemical structure of GBD-9

GC73490

GBD-9

Also known as 5-[[9-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-9-oxononyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

GBD-9 is a double-mechanism degrader that efficiently degrades BTK and GSPT1 by recruiting the E3 ligase cereblon (CRBN)

ChemicalCAS2864408-92-2MW797.9FormulaC44H47N9O6
CAS number
2864408-92-2
Molecular weight
797.9
Formula
C44H47N9O6
Solubility
DMSO ： 100 mg/mL (125·33 mM; Need ultrasonic)
InChIKey
DCJYQURCBHSFEP-OSRRZMJMSA-N
Catalogue number
GC73490
Brand
GLPBIO
Computed properties PubChem CID 168324318 · XLogP 5.5 · TPSA 195 Ų · H-bond donors 3
XLogP
5.5
TPSA
195 Ų
H-bond donors
3
H-bond acceptors
11
Rotatable bonds
15
Heavy atoms
59

SMILES C1C[C@H](CN(C1)C(=O)CCCCCCCCNC2=CC3=C(C=C2)C(=O)N(C3=O)C4CCC(=O)NC4=O)N5C6=NC=NC(=C6C(=N5)C7=CC=C(C=C7)OC8=CC=CC=C8)N

Computed descriptors from PubChem (CID 168324318), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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