Loading...
Chemical structure of HDAC6 degrader-3

GC73385

HDAC6 degrader-3

Also known as 4-[[5-[8-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]octanoylamino]-2-methylbenzimidazol-1-yl]methyl]-3-fluoro-N-hydroxybenzamide;2,2,2-trifluoroacetic acid

HDAC6 degrader-3 is a potent and selective HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with a DC50 value of 19·4 nM

ChemicalCAS2785404-83-1MW883.8FormulaC41H41F4N7O11
CAS number
2785404-83-1
Molecular weight
883.8
Formula
C41H41F4N7O11
Solubility
DMSO ： 100 mg/mL (113·15 mM; Need ultrasonic)
InChIKey
YHRIRNOBNMKZIJ-UHFFFAOYSA-N
Catalogue number
GC73385
Brand
GLPBIO
Computed properties PubChem CID 166642469 · TPSA 255 Ų · H-bond donors 6 · H-bond acceptors 16
TPSA
255 Ų
H-bond donors
6
H-bond acceptors
16
Rotatable bonds
16
Heavy atoms
63

SMILES CC1=NC2=C(N1CC3=C(C=C(C=C3)C(=O)NO)F)C=CC(=C2)NC(=O)CCCCCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C5=O)C6CCC(=O)NC6=O.C(=O)(C(F)(F)F)O

Computed descriptors from PubChem (CID 166642469), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.