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Chemical structure of HDAC6 degrader-1

GC70691

HDAC6 degrader-1

Also known as 4-[[4-[1-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethoxy]ethoxy]ethyl]triazol-4-yl]butyl-(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide

HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase

ChemicalCAS2439058-23-6MW795.84FormulaC40H45N9O9
CAS number
2439058-23-6
Molecular weight
795.84
Formula
C40H45N9O9
Solubility
DMSO ： 100 mg/mL (125·65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
NLVMRCQAKUCFIA-UHFFFAOYSA-N
Catalogue number
GC70691
Brand
GLPBIO
Computed properties PubChem CID 162640960 · XLogP 1.9 · TPSA 226 Ų · H-bond donors 5
XLogP
1.9
TPSA
226 Ų
H-bond donors
5
H-bond acceptors
12
Rotatable bonds
20
Heavy atoms
58

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCN4C=C(N=N4)CCCCN(CC5=CC=C(C=C5)C(=O)NO)C(=O)NC6=CC=CC=C6

Computed descriptors from PubChem (CID 162640960), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.