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Chemical structure of JS25

GC73364

JS25

Also known as N-[3-[8-[4-(methanesulfonamido)phenyl]-2-oxobenzo[h][1,6]naphthyridin-1-yl]-5-methylphenyl]prop-2-enamide

JS25 is a selective and covalent inhibitor of BTK that inactivates BTK with an IC50 value of 5·8 nM by chelating Tyr551

ChemicalCAS2411771-95-2MW524.59FormulaC29H24N4O4S
CAS number
2411771-95-2
Molecular weight
524.59
Formula
C29H24N4O4S
Solubility
DMSO ： 20 mg/mL (38·13 mM; ultrasonic and warming and heat to 60°C)
InChIKey
WPVJPKXENBARHX-UHFFFAOYSA-N
Catalogue number
GC73364
Brand
GLPBIO
Computed properties PubChem CID 155368276 · XLogP 4.1 · TPSA 117 Ų · H-bond donors 2
XLogP
4.1
TPSA
117 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
38

SMILES CC1=CC(=CC(=C1)N2C(=O)C=CC3=CN=C4C=C(C=CC4=C32)C5=CC=C(C=C5)NS(=O)(=O)C)NC(=O)C=C

Computed descriptors from PubChem (CID 155368276), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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