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Chemical structure of Smurf1-IN-1

GC73229

Smurf1-IN-1

Also known as 1-(2-chloro-4-cyclopropylphenyl)-N-(1-cyclohexyl-2,3-dimethyl-5-oxopyrazol-4-yl)-5-methyltriazole-4-carboxamide

Smurf1-IN-1 is an orally active and selective inhibitor of specific E3 ubiquitin protein ligase 1 (SMURF1) with an IC50 of 92 nM

ChemicalCAS1824708-03-3MW468.98FormulaC24H29ClN6O2
CAS number
1824708-03-3
Molecular weight
468.98
Formula
C24H29ClN6O2
Solubility
DMSO ： 100 mg/mL (213·23 mM; Need ultrasonic)
InChIKey
DJCHYTWZRDUVHQ-UHFFFAOYSA-N
Catalogue number
GC73229
Brand
GLPBIO
Computed properties PubChem CID 118513267 · XLogP 5 · TPSA 83.4 Ų · H-bond donors 1
XLogP
5
TPSA
83.4 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
33

SMILES CC1=C(C(=O)N(N1C)C2CCCCC2)NC(=O)C3=C(N(N=N3)C4=C(C=C(C=C4)C5CC5)Cl)C

Computed descriptors from PubChem (CID 118513267), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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