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Chemical structure of Snail/HDAC-IN-1

GC69917

Snail/HDAC-IN-1

Also known as N-(2-amino-4-fluorophenyl)-4-[[4-[(5-methyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]sulfanylmethyl]benzamide

Snail/HDAC-IN-1 is an effective dual-target inhibitor of Snail/HDAC· It has strong inhibitory activity against HDAC1 with an IC50 of 0·405 μM and a strong inhibitory effect on Snail with a Kd of 0·18 μM· Snail/HDAC-IN-1 increases histone H4 acetylation in HCT-116 cells and reduces the expression of Snail protein, thereby inducing apoptosis in cells

ChemicalCAS2415281-52-4MW488.54FormulaC24H21FN8OS
CAS number
2415281-52-4
Molecular weight
488.54
Formula
C24H21FN8OS
InChIKey
FWJQLBLNLGDLIU-UHFFFAOYSA-N
Catalogue number
GC69917
Brand
GLPBIO
Computed properties PubChem CID 153528580 · XLogP 3.9 · TPSA 151 Ų · H-bond donors 4
XLogP
3.9
TPSA
151 Ų
H-bond donors
4
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
35

SMILES CC1=CC(=NN1)NC2=NC(=NN3C2=CC=C3)SCC4=CC=C(C=C4)C(=O)NC5=C(C=C(C=C5)F)N

Computed descriptors from PubChem (CID 153528580), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.