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Chemical structure of AK-2292

GC73203

AK-2292

Also known as [[2-[[(2S)-1-[(2S)-2-[[3-[5-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]pent-4-ynyl-methylamino]-3-oxopropyl]-[4-(1,3-thiazol-2-yl)phenyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl]-1-benzothiophen-5-yl]-difluoromethyl]phosphonic acid

AK-2292 is a potent and selective STAT5 PROTAC degrader, with a DC50 of 0·10 μM

ChemicalCAS2984506-77-4MW1070.13FormulaC52H54F2N7O10PS2
CAS number
2984506-77-4
Molecular weight
1070.13
Formula
C52H54F2N7O10PS2
Solubility
DMSO ： 125 mg/mL (116·81 mM; Need ultrasonic)
InChIKey
LOPYPDQOHNOVBM-QOIUHGAOSA-N
Catalogue number
GC73203
Brand
GLPBIO
Computed properties PubChem CID 166594150 · XLogP 5.3 · TPSA 283 Ų · H-bond donors 4
XLogP
5.3
TPSA
283 Ų
H-bond donors
4
H-bond acceptors
15
Rotatable bonds
17
Heavy atoms
74

SMILES CC(C)(C)[C@@H](C(=O)N1CCC[C@H]1C(=O)N(CCC(=O)N(C)CCCC#CC2=C3CN(C(=O)C3=CC=C2)C4CCC(=O)NC4=O)C5=CC=C(C=C5)C6=NC=CS6)NC(=O)C7=CC8=C(S7)C=CC(=C8)C(F)(F)P(=O)(O)O

Computed descriptors from PubChem (CID 166594150), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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