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Chemical structure of AKT-IN-6

GC62190

AKT-IN-6

Also known as 5-[2-[(2S)-1-amino-3-(3-fluorophenyl)propan-2-yl]-1-oxo-3H-isoindol-5-yl]-1-methylpyrazole-4-carbonitrile

AKT-IN-6 (Example 13) is a potent Akt inhibitor· AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s ＜ 500nM, respectively· (patent WO2013056015A1)

ChemicalCAS1430056-54-4MW389.43FormulaC22H20FN5O
CAS number
1430056-54-4
Molecular weight
389.43
Formula
C22H20FN5O
Solubility
DMSO ： 125 mg/mL (320·98 mM; Need ultrasonic)
InChIKey
QXRHOURHCGFDIM-IBGZPJMESA-N
Catalogue number
GC62190
Brand
GLPBIO
Computed properties PubChem CID 89499684 · XLogP 1.8 · TPSA 87.9 Ų · H-bond donors 1
XLogP
1.8
TPSA
87.9 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
29

SMILES CN1C(=C(C=N1)C#N)C2=CC3=C(C=C2)C(=O)N(C3)[C@@H](CC4=CC(=CC=C4)F)CN

Computed descriptors from PubChem (CID 89499684), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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