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Chemical structure of AZ'6421

GC73046

AZ'6421

Also known as (2S,4R)-1-[(2S)-2-[[2-[3-[3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-1-yl]phenoxy]propoxy]propoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

AZ'6421 acts as Protcolysis Targeting Chimera (PROTAC) to selectively degrade estrogen receptor alpha

ChemicalCAS2361115-35-5MW975.17FormulaC52H65F3N6O7S
CAS number
2361115-35-5
Molecular weight
975.17
Formula
C52H65F3N6O7S
Solubility
DMSO ： ≥ 100 mg/mL (102·55 mM)
InChIKey
PMXVLCRRMGVGJX-DXALMRNBSA-N
Catalogue number
GC73046
Brand
GLPBIO
Computed properties PubChem CID 138693568 · XLogP 7.8 · TPSA 187 Ų · H-bond donors 4
XLogP
7.8
TPSA
187 Ų
H-bond donors
4
H-bond acceptors
13
Rotatable bonds
21
Heavy atoms
69

SMILES C[C@@H]1CC2=C([C@H](N1CC(C)(C)F)C3=C(C=C(C=C3F)OCCCOCCCOCC(=O)N[C@H](C(=O)N4C[C@@H](C[C@H]4C(=O)NCC5=CC=C(C=C5)C6=C(N=CS6)C)O)C(C)(C)C)F)NC7=CC=CC=C27

Computed descriptors from PubChem (CID 138693568), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.