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Chemical structure of AZ PFKFB3 26

GC34479

AZ PFKFB3 26

Also known as (2S)-N-[4-[3-cyano-1-(2-methylpropyl)indol-5-yl]oxyphenyl]pyrrolidine-2-carboxamide

AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 23 nM· AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2·06 and 0·384 μM, respectively

ChemicalCAS1704740-52-2MW402.49FormulaC24H26N4O2
CAS number
1704740-52-2
Molecular weight
402.49
Formula
C24H26N4O2
Solubility
DMSO： 5 mg/mL (12·42 mM; ultrasonic and adjust pH to 3 with HCl)
InChIKey
OOGHGWKBJXQNEJ-QFIPXVFZSA-N
Catalogue number
GC34479
Brand
GLPBIO
Computed properties PubChem CID 118735769 · XLogP 3.8 · TPSA 79.1 Ų · H-bond donors 2
XLogP
3.8
TPSA
79.1 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
30

SMILES CC(C)CN1C=C(C2=C1C=CC(=C2)OC3=CC=C(C=C3)NC(=O)[C@@H]4CCCN4)C#N

Computed descriptors from PubChem (CID 118735769), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
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