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Chemical structure of JAK1-IN-13

GC71475

JAK1-IN-13

Also known as N-methyl-4-[[(2S,4S)-2-methyl-1-[[4-(trifluoromethyl)phenyl]methyl]piperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide

JAK1-IN-13 (compound 36b) is an orally active, potent and highly selective inhibitor of JAK1 with an IC50 of 0·044 nM

ChemicalCAS2778330-90-6MW445.48FormulaC23H26F3N5O
CAS number
2778330-90-6
Molecular weight
445.48
Formula
C23H26F3N5O
Solubility
DMSO ： 100 mg/mL (224·48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
LLXUFTFQOVBHRV-YOEHRIQHSA-N
Catalogue number
GC71475
Brand
GLPBIO
Computed properties PubChem CID 167089566 · XLogP 4.5 · TPSA 73.1 Ų · H-bond donors 3
XLogP
4.5
TPSA
73.1 Ų
H-bond donors
3
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
32

SMILES C[C@H]1C[C@H](CCN1CC2=CC=C(C=C2)C(F)(F)F)NC3=C4C=CNC4=NC=C3C(=O)NC

Computed descriptors from PubChem (CID 167089566), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.