Loading...
Chemical structure of JAK1-IN-3

GC33036

JAK1-IN-3

Also known as (2R)-N-[3-[2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide

JAK1-IN-3 (AZD4205) is a selective JAK1 inhibitor, with an IC50 of 73 nM, weakly inhibits JAK2 (IC50>14·7 μM), and shows little inhibition on JAK3 (IC50>30 μM)

ChemicalCAS2091134-68-6MW489.57FormulaC25H31N9O2
CAS number
2091134-68-6
Molecular weight
489.57
Formula
C25H31N9O2
Solubility
DMSO： 250 mg/mL (510·65 mM)
InChIKey
CVCVOSPZEVINRM-MRXNPFEDSA-N
Catalogue number
GC33036
Brand
GLPBIO
Computed properties PubChem CID 126715380 · XLogP 1.9 · TPSA 116 Ų · H-bond donors 3
XLogP
1.9
TPSA
116 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
36

SMILES C[C@H](C(=O)NC1=CC=CC2=C1NC=C2C3=NC(=NC=C3)NC4=CN(N=C4OC)C)N5CCN(CC5)C

Computed descriptors from PubChem (CID 126715380), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.