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Chemical structure of JAK1-IN-8

GC63029

JAK1-IN-8

Also known as N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-3-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

JAK1-IN-8, a potent JAK1 inhibitor (IC50＜500 nM), compound 28, extracted from patent WO2016119700A1

ChemicalCAS1973485-18-5MW442.51FormulaC22H23FN4O3S
CAS number
1973485-18-5
Molecular weight
442.51
Formula
C22H23FN4O3S
Solubility
DMSO ： 125 mg/mL (282·48 mM; Need ultrasonic)
InChIKey
QDYVZZJCRDVVQG-UHFFFAOYSA-N
Catalogue number
GC63029
Brand
GLPBIO
Computed properties PubChem CID 122462620 · XLogP 2.5 · TPSA 92.2 Ų · H-bond donors 1
XLogP
2.5
TPSA
92.2 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
31

SMILES C1CC1C(=O)NC2=CN3C(=N2)C=CC=C3C4=CC(=C(C=C4)CN5CCS(=O)(=O)CC5)F

Computed descriptors from PubChem (CID 122462620), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.