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Chemical structure of mGluR5 antagonist-1

GC71331

mGluR5 antagonist-1

Also known as N-(4-methoxyphenyl)-7-methyl-4-(2-phenylethynyl)pyrrolo[2,3-d]pyrimidine-6-carboxamide

mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC50 value of 11·5 nM· mGluR5 antagonist-1 has anti-depressant effect

ChemicalCAS2761424-76-2MW382.41FormulaC23H18N4O2
CAS number
2761424-76-2
Molecular weight
382.41
Formula
C23H18N4O2
Solubility
DMSO ： 200 mg/mL (523·00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
OIYWWKBIBPZHKJ-UHFFFAOYSA-N
Catalogue number
GC71331
Brand
GLPBIO
Computed properties PubChem CID 162692137 · XLogP 3.8 · TPSA 69 Ų · H-bond donors 1
XLogP
3.8
TPSA
69 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
5
Heavy atoms
29

SMILES CN1C(=CC2=C(N=CN=C21)C#CC3=CC=CC=C3)C(=O)NC4=CC=C(C=C4)OC

Computed descriptors from PubChem (CID 162692137), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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