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Chemical structure of mHTT-IN-2

GC75590

mHTT-IN-2

Also known as 5-[(3R)-3-(cyclopropylamino)pyrrolidin-1-yl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)pyrazine-2-carboxamide

mHTT-IN-2 (compound 27) is a potent inhibitor (EC50=0·066 μM) of mutant huntingtin (mHTT)· mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene· mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models· mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy

ChemicalCAS2743336-70-9MW395.43FormulaC20H22FN7O
CAS number
2743336-70-9
Molecular weight
395.43
Formula
C20H22FN7O
Solubility
DMSO： 100 mg/mL (252·89 mM; Need ultrasonic)
InChIKey
VPWHAEPYJSEFEH-CQSZACIVSA-N
Catalogue number
GC75590
Brand
GLPBIO
Computed properties PubChem CID 166508076 · XLogP 2.1 · TPSA 87.5 Ų · H-bond donors 2
XLogP
2.1
TPSA
87.5 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
29

SMILES CC1=CN2C=C(C=C(C2=N1)F)NC(=O)C3=CN=C(C=N3)N4CC[C@H](C4)NC5CC5

Computed descriptors from PubChem (CID 166508076), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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