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Chemical structure of APG-2449

GC71323

APG-2449

Also known as 5-chloro-2-N-[5-methyl-4-[1-(oxan-4-yl)-3,6-dihydro-2H-pyridin-4-yl]-2-propan-2-yloxyphenyl]-4-N-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine

APG-2449 is an orally active ALK/ROS1/FAK inhibitor

ChemicalCAS2196186-84-0MW640.24FormulaC33H42ClN5O4S
CAS number
2196186-84-0
Molecular weight
640.24
Formula
C33H42ClN5O4S
Solubility
DMSO ： 25 mg/mL (39·05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
YWPHBSHEGTZPNS-UHFFFAOYSA-N
Catalogue number
GC71323
Brand
GLPBIO
Computed properties PubChem CID 138678712 · XLogP 6.9 · TPSA 114 Ų · H-bond donors 2
XLogP
6.9
TPSA
114 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
10
Heavy atoms
44

SMILES CC1=CC(=C(C=C1C2=CCN(CC2)C3CCOCC3)OC(C)C)NC4=NC=C(C(=N4)NC5=CC=CC=C5S(=O)(=O)C(C)C)Cl

Computed descriptors from PubChem (CID 138678712), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.