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Chemical structure of APG-1387

GC62640

APG-1387

Also known as (5S,8S,10aR)-3-[3-[[(5S,8S,10aR)-8-(benzhydrylcarbamoyl)-5-[[(2S)-2-(methylamino)propanoyl]amino]-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocin-3-yl]sulfonyl]phenyl]sulfonyl-N-benzhydryl-5-[[(2S)-2-(methylamino)propanoyl]amino]-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide

APG-1387, a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP)· APG-1387 induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads to apoptosis· APG-1387 can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma

ChemicalCAS1570231-89-8MW1157.4FormulaC60H72N10O10S2
CAS number
1570231-89-8
Molecular weight
1157.4
Formula
C60H72N10O10S2
Solubility
DMSO ： 50 mg/mL (43·20 mM; Need ultrasonic)|Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
AKLBERUGKZNEJY-RTEPGWBGSA-N
Catalogue number
GC62640
Brand
GLPBIO
Computed properties PubChem CID 73336238 · XLogP 4.5 · TPSA 273 Ų · H-bond donors 6
XLogP
4.5
TPSA
273 Ų
H-bond donors
6
H-bond acceptors
14
Rotatable bonds
18
Heavy atoms
82

SMILES C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)S(=O)(=O)C5=CC(=CC=C5)S(=O)(=O)N6CC[C@H]7CC[C@H](N7C(=O)[C@H](C6)NC(=O)[C@H](C)NC)C(=O)NC(C8=CC=CC=C8)C9=CC=CC=C9)NC

Computed descriptors from PubChem (CID 73336238), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.