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Chemical structure of GSK-3 inhibitor 3

GC71302

GSK-3 inhibitor 3

Also known as 2-(4-cyanoanilino)-N-[4-(4-fluorophenyl)-3-pyridinyl]pyrimidine-4-carboxamide

GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0·35 nM and 0·25 nM for GSK-3α and GSK-3β, respectively

ChemicalCAS2227279-84-5MW410.4FormulaC23H15FN6O
CAS number
2227279-84-5
Molecular weight
410.4
Formula
C23H15FN6O
Solubility
DMSO ： 50 mg/mL (121·83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
QLWFPXXGZGCHFQ-UHFFFAOYSA-N
Catalogue number
GC71302
Brand
GLPBIO
Computed properties PubChem CID 134556469 · XLogP 3.6 · TPSA 104 Ų · H-bond donors 2
XLogP
3.6
TPSA
104 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
31

SMILES C1=CC(=CC=C1C#N)NC2=NC=CC(=N2)C(=O)NC3=C(C=CN=C3)C4=CC=C(C=C4)F

Computed descriptors from PubChem (CID 134556469), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.