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Chemical structure of GSK-25

GC38791

GSK-25

Also known as 4-(4-chloro-2-fluorophenyl)-2-(2-chloro-4-pyridinyl)-N-(6-fluoro-1H-indazol-5-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide

GSK-25 is a potent, selective and orally bioavailable ROCK1 inhibitor (IC50=7 nM)

ChemicalCAS874119-56-9MW513.33FormulaC24H16Cl2F2N6O
CAS number
874119-56-9
Molecular weight
513.33
Formula
C24H16Cl2F2N6O
Solubility
DMSO： 100 mg/mL (194·81 mM)
InChIKey
KZYAHEIPPAPADQ-UHFFFAOYSA-N
Catalogue number
GC38791
Brand
GLPBIO
Computed properties PubChem CID 11548023 · XLogP 4.3 · TPSA 95.1 Ų · H-bond donors 3
XLogP
4.3
TPSA
95.1 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
35

SMILES CC1=C(C(N=C(N1)C2=CC(=NC=C2)Cl)C3=C(C=C(C=C3)Cl)F)C(=O)NC4=C(C=C5C(=C4)C=NN5)F

Computed descriptors from PubChem (CID 11548023), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.