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Chemical structure of TMX-4153

GC71220

TMX-4153

Also known as (2S,4R)-1-[(2S)-2-[[7-[2-[5-[[5-chloro-4-(3-phenylphenyl)pyrimidin-2-yl]amino]-3-pyridinyl]-1-oxo-2,8-diazaspiro[4.5]decan-8-yl]-7-oxoheptanoyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

TMX-4153 is a bivalent degrader

ChemicalCAS2867519-91-1MW1079.74FormulaC59H67ClN10O6S
CAS number
2867519-91-1
Molecular weight
1079.74
Formula
C59H67ClN10O6S
Solubility
DMSO ： 100 mg/mL (92·61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
NIQFZCJNEODJTE-CSIWTOAPSA-N
Catalogue number
GC71220
Brand
GLPBIO
Computed properties PubChem CID 166136687 · XLogP 7.8 · TPSA 231 Ų · H-bond donors 4
XLogP
7.8
TPSA
231 Ų
H-bond donors
4
H-bond acceptors
12
Rotatable bonds
18
Heavy atoms
77

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCC(=O)N4CCC5(CC4)CCN(C5=O)C6=CN=CC(=C6)NC7=NC=C(C(=N7)C8=CC=CC(=C8)C9=CC=CC=C9)Cl)O

Computed descriptors from PubChem (CID 166136687), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.