GC65502
TM-1
Also known as 3-(3,4-dimethoxyphenyl)-7-[2-[4-(2-hydroxyethyl)piperazin-1-yl]ethoxy]-4-methylchromen-2-one
TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase (PDHK1)· TM-1 inhibits PDHK1 and PDHK2 with IC50s of 2·97 μM and 5·2 μM, respectively· TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation
ChemicalCAS921099-13-0MW468.54FormulaC26H32N2O6
- CAS number
- 921099-13-0
- Molecular weight
- 468.54
- Formula
- C26H32N2O6
- InChIKey
- FJPOSFVCWXTUDP-UHFFFAOYSA-N
- Catalogue number
- GC65502
- Brand
- GLPBIO
Computed properties PubChem CID 16424570 · XLogP 2.5 · TPSA 80.7 Ų · H-bond donors 1
- XLogP
- 2.5
- TPSA
- 80.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Rotatable bonds
- 9
- Heavy atoms
- 34
SMILES CC1=C(C(=O)OC2=C1C=CC(=C2)OCCN3CCN(CC3)CCO)C4=CC(=C(C=C4)OC)OC
Computed descriptors from PubChem (CID 16424570), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il