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Chemical structure of Protein kinase inhibitor 1 hydrochloride

GC69769

Protein kinase inhibitor 1 hydrochloride

Also known as (5E)-5-[[6-oxo-5-(6-piperazin-1-yl-3-pyridinyl)-1H-pyridin-3-yl]methylidene]-1,3-thiazolidine-2,4-dione;hydrochloride

Protein kinase inhibitor 1 hydrochloride is an effective inhibitor of HIPK2, with IC50 values of 136 and 74 nM for HIPK1 and HIPK2 respectively, and a Kd value of 9·5 nM for HIPK2

ChemicalCAS2321337-71-5MW419.89FormulaC18H18ClN5O3S
CAS number
2321337-71-5
Molecular weight
419.89
Formula
C18H18ClN5O3S
Solubility
H2O ： 9·09 mg/mL (21·65 mM; Need ultrasonic)
InChIKey
PSLSZGRUEDWPNC-XHIXCECLSA-N
Catalogue number
GC69769
Brand
GLPBIO
Computed properties PubChem CID 134611631 · TPSA 129 Ų · H-bond donors 4 · H-bond acceptors 7
TPSA
129 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
3
Heavy atoms
28

SMILES C1CN(CCN1)C2=NC=C(C=C2)C3=CC(=CNC3=O)/C=C/4\C(=O)NC(=O)S4.Cl

Computed descriptors from PubChem (CID 134611631), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.