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Chemical structure of Protein Kinase P34 (cd2) Substrate

GA23390

Protein Kinase P34 (cd2) Substrate

Also known as (4S)-4-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-carboxypropanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]hexanoyl]amino]hexanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-5-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-1-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-carboxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

CSH-103, ADAQHATPPKKKRKVEDPKDF, based on the simian virus 40 large T antigen sequence, is a specific substrate for p34 cdc2 protein kinase (Km= 0·07 mM)· It is not phosphorylated by other kinases (casein kinase I/II, cAMP-dependent protein kinase, glycogen synthase kinase 3, phosphorylase b kinase, protein kinase C, calmodulin and kinase II)

ChemicalCAS135546-44-0MW2406.73FormulaC106H172N32O32
CAS number
135546-44-0
Molecular weight
2406.73
Formula
C106H172N32O32
Solubility
Soluble in DMSO
InChIKey
SZPOEPIILXQMAF-YABPZEJXSA-N
Catalogue number
GA23390
Brand
GLPBIO
Computed properties PubChem CID 71311698 · XLogP -20.9 · TPSA 1050 Ų · H-bond donors 34
XLogP
-20.9
TPSA
1050 Ų
H-bond donors
34
H-bond acceptors
40
Rotatable bonds
81
Heavy atoms
170

SMILES C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC5=CNC=N5)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)N)O

Computed descriptors from PubChem (CID 71311698), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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