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Chemical structure of NF-κB/MAPK-IN-1

GC69556

NF-κB/MAPK-IN-1

Also known as (E)-N-[4-(2-acetyl-5-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide

NF-κB/MAPK-IN-1 (compound 11a) is an effective inhibitor of the NF-κB and MAPK pathways· It has inhibitory effects on NO production, with an IC50 of 6·96 μM· NF-κB/MAPK-IN-1 also inhibits LPS-induced iNOS, COX-2, ERα, and P38 activation· It can inhibit macrophage inflammatory response induced by LPS· NF-κB/MAPK-IN-1 can be used for research on rheumatoid arthritis (RA)

ChemicalCAS2413940-56-2MW477.51FormulaC27H27NO7
CAS number
2413940-56-2
Molecular weight
477.51
Formula
C27H27NO7
Solubility
DMSO ： 100 mg/mL (209·42 mM; Need ultrasonic)
InChIKey
PUWGXAJLVXPFFP-AWNIVKPZSA-N
Catalogue number
GC69556
Brand
GLPBIO
Computed properties PubChem CID 148976305 · XLogP 4.3 · TPSA 92.3 Ų · H-bond donors 1
XLogP
4.3
TPSA
92.3 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
10
Heavy atoms
35

SMILES CC(=O)C1=C(C=C(C=C1)OC)OC2=CC=C(C=C2)NC(=O)/C=C/C3=CC(=C(C(=C3)OC)OC)OC

Computed descriptors from PubChem (CID 148976305), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.