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Chemical structure of NF-κB-IN-1

GC62070

NF-κB-IN-1

Also known as (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylidene]hepta-1,6-diene-3,5-dione

NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor· NF-κB-IN-1 directly inhibits IKK to block NF-κB activation· NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells

ChemicalCAS1227098-15-8MW530.57FormulaC31H30O8
CAS number
1227098-15-8
Molecular weight
530.57
Formula
C31H30O8
Solubility
DMSO ： 50 mg/mL (94·24 mM)
InChIKey
AYIYVEPNEPUJCF-GNXRPPCSSA-N
Catalogue number
GC62070
Brand
GLPBIO
Computed properties PubChem CID 49851904 · XLogP 5.6 · TPSA 101 Ų · H-bond donors 1
XLogP
5.6
TPSA
101 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
12
Heavy atoms
39

SMILES COC1=C(C=C(C=C1)/C=C/C(=O)C(=CC2=CC(=C(C=C2)O)OC)C(=O)/C=C/C3=CC(=C(C=C3)OC)OC)OC

Computed descriptors from PubChem (CID 49851904), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.