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Chemical structure of KV2 channel inhibitor-1

GC69343

KV2 channel inhibitor-1

Also known as 3-(3-chlorophenyl)-N-[2-(1,3-thiazol-4-yl)-3H-benzimidazol-5-yl]butanamide

KV2 channel inhibitor-1 is a selective inhibitor of KV2 channels, with IC50 values of 0·2 μM and 0·41 μM for KV2·1 and KV2·2, respectively· It has good selectivity for KV1·2 (IC50>10 μM)· The selectivity of KV2 channel inhibitor-1 for NaV channels and other KV channels is more than 10 times higher, and it exhibits weak activity on CaV channels

ChemicalCAS689297-68-5MW396.89FormulaC20H17ClN4OS
CAS number
689297-68-5
Molecular weight
396.89
Formula
C20H17ClN4OS
Solubility
DMSO ： 250 mg/mL (629·90 mM; Need ultrasonic)
InChIKey
MRQZOINSVKHDQS-UHFFFAOYSA-N
Catalogue number
GC69343
Brand
GLPBIO
Computed properties PubChem CID 10023694 · XLogP 4.5 · TPSA 98.9 Ų · H-bond donors 2
XLogP
4.5
TPSA
98.9 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
5
Heavy atoms
27

SMILES CC(CC(=O)NC1=CC2=C(C=C1)N=C(N2)C3=CSC=N3)C4=CC(=CC=C4)Cl

Computed descriptors from PubChem (CID 10023694), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Lead time
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