Loading...
Chemical structure of K+ Channel inhibitor 1734

GB40250

K+ Channel inhibitor 1734

Also known as methyl 7-(2,3-dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate

Building block for synthesis of dihydropyrazolopyrimidine inhibitors of Kv1·5 (IKur)· The ethylester analog of inhibitor 1734 is a modest inhibitor itself (IC50 value 1·1 µM for human Kv1·5), but exhibiting encouraging KV1·5 versus L-type calcium channel selectivity

ChemicalCAS343240-54-0MW338.19FormulaC15H13Cl2N3O2
CAS number
343240-54-0
Molecular weight
338.19
Formula
C15H13Cl2N3O2
InChIKey
FFVXEFSTAAFKEN-UHFFFAOYSA-N
Catalogue number
GB40250
Brand
GLPBIO
Computed properties PubChem CID 135486149 · XLogP 3.6 · TPSA 56.2 Ų · H-bond donors 1
XLogP
3.6
TPSA
56.2 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
22

SMILES CC1=C(C(N2C(=CC=N2)N1)C3=C(C(=CC=C3)Cl)Cl)C(=O)OC

Computed descriptors from PubChem (CID 135486149), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.