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Chemical structure of IW927

GC69304

IW927

Also known as 4-(3-methoxyphenyl)-10-(3-morpholin-4-ylpropyl)-11-sulfanylidene-5-thia-1,10-diazatricyclo[6.3.0.02,6]undeca-2(6),3,7-trien-9-one

IW927 is an effective small molecule antagonist that can block the binding of TNF-α to TNFRc1, with an IC50 value of 50 nM· It can also disrupt TNF-α-induced IκB phosphorylation, with an IC50 value of 600 nM

ChemicalCAS389142-48-7MW441.57FormulaC22H23N3O3S2
CAS number
389142-48-7
Molecular weight
441.57
Formula
C22H23N3O3S2
InChIKey
RQGIIRZJMKNCHS-UHFFFAOYSA-N
Catalogue number
GC69304
Brand
GLPBIO
Computed properties PubChem CID 10433428 · XLogP 3.8 · TPSA 107 Ų · H-bond donors 0
XLogP
3.8
TPSA
107 Ų
H-bond donors
0
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
30

SMILES COC1=CC=CC(=C1)C2=CC3=C(S2)C=C4N3C(=S)N(C4=O)CCCN5CCOCC5

Computed descriptors from PubChem (CID 10433428), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.