Loading...
Chemical structure of CDK12-IN-5

GC68845

CDK12-IN-5

Also known as N-[(4,5-difluoro-1H-benzimidazol-2-yl)methyl]-2-morpholin-4-yl-8-(trifluoromethyl)pyrazolo[1,5-a][1,3,5]triazin-4-amine

CDK12-IN-5 is a pyrazole-triazine compound that is an effective inhibitor of CDK12, with an IC50 of 23·9 nM at high ATP (2 mM)· CDK12-IN-5 has no effect on CDK2/Cyclin E (IC50=173 μM) and CDK9/Cyclin T1 (IC50=127 μM) at high ATP (2 mM) (WO2021116178A1)

ChemicalCAS2651200-35-8MW454.36FormulaC18H15F5N8O
CAS number
2651200-35-8
Molecular weight
454.36
Formula
C18H15F5N8O
Solubility
DMSO ： 125 mg/mL (275·11 mM; Need ultrasonic)
InChIKey
XFZQHKMIWRKKCU-UHFFFAOYSA-N
Catalogue number
GC68845
Brand
GLPBIO
Computed properties PubChem CID 156482226 · XLogP 2.7 · TPSA 96.3 Ų · H-bond donors 2
XLogP
2.7
TPSA
96.3 Ų
H-bond donors
2
H-bond acceptors
12
Rotatable bonds
4
Heavy atoms
32

SMILES C1COCCN1C2=NC3=C(C=NN3C(=N2)NCC4=NC5=C(N4)C=CC(=C5F)F)C(F)(F)F

Computed descriptors from PubChem (CID 156482226), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.